Basic Information
VIS ID
TVIS30014818
Fusion event
HIV-chr11 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
74124466/74413421 (Hg38)
End
74124366/74413421 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/14088; hsa-let-7a-2/Downstream/306847;
Nearest TSS
ENST00000527297/Upstream/14948; ENST00000530510/Downstream/41927;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/14529, chr11-CpG: 50/Downstream/53709
Nearby gene
PGM2L1(No orient, 14964)
Upstream sequence
agagctgccacaGGTGGCAATAGGGGGGAAAAATGCAGCTCAAGAGCTAGAAAATACAAACCATATAGTGTATAATTAAGAATTTACCATAGTAACTTAT
Downstream sequence
TTAGGAACTATAGCATGTATCCCATAAAGTTACTGAGCATATCTGCATAATTTATCCAACACTTAGATCAGTGCCTAGCCTGGTCCTGTTGCAAGCACAG
Target sequence
agagctgccacaGGTGGCAATAGGGGGGAAAAATGCAGCTCAAGAGCTAGAAAATACAAACCATATAGTGTATAATTAAGAATTTACCATAGTAACTTAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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