Basic Information
VIS ID
TVIS30014819
Fusion event
HIV-GDPD5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
75215968/75504923 (Hg38)
End
75215995/75504923 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
GDPD5
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-188-3p ; hsa-mir-4291 ; hsa-mir-4683 ; hsa-mir-146b-3p ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-7976 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-6889-3p ; hsa-mir-1205 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-922 ; hsa-mir-652-3p ; hsa-mir-3617-3p ; hsa-mir-6760-5p ; hsa-mir-3943 ; hsa-mir-383-5p ; hsa-mir-873-5p ; hsa-mir-874-3p
Nearest miRNA
hsa-mir-10392/Upstream/169737; hsa-let-7a-2/Downstream/3897099;
Nearest TSS
ENST00000527297/Upstream/14172; ENST00000526242/Downstream/20333;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/74119, chr11-CpG: 160/Downstream/20221
Upstream sequence
atttttaaaaaTACTCTCACTCggccaggcacagtggctcacgcctgtaattccagcactttgggaggccgaggcaggcggatcatgaggtcaggagttc
Downstream sequence
cccagtctctattaaaaatacaaaaattagccgggtgtgcgcatgcctgtaatcccagctactcaggaagctgaggcaggagaactgcttgaacccggga
Target sequence
gagaccagcccgaccaacttggtgaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate