Basic Information
VIS ID
TVIS30014820
Fusion event
HIV-UVRAG integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
75672478/75961434 (Hg38)
End
75672570/75961434 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
UVRAG
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-33a-5p ; hsa-mir-301a-3p ; hsa-mir-205-5p ; hsa-mir-183-5p ; hsa-mir-203a-5p
Nearest miRNA
hsa-mir-10392/Upstream/626248; hsa-let-7a-2/Downstream/3440588;
Nearest TSS
ENST00000527297/Upstream/30574; ENST00000530501/Downstream/29;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/145553, chr11-CpG: 79/Downstream/202959
Nearest cancer related gene
UVRAG(TSG, No orient, 0)
Upstream sequence
GAGTTCATTATTAATTCTATGTATCCTCCAGGTTTGTCATTTATATCTGAGGCTCTTTGTTGAGTTTACTGTTAACTCATTTACATTTTTCTATAACTTA
Downstream sequence
TCACATCTACAAGCAATGAACTGGTAGGTTTTTATGTATTTACCTGTTTACACTTCTTGTTTTCTAAAGGAGAGTATCATATTCTTCTAGGGTTAATTTT
Target sequence
TATTTCTAGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate