Basic Information
VIS ID
TVIS30014821
Fusion event
HIV-UVRAG integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
75677218/75966174 (Hg38)
End
75677155/75966174 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
UVRAG
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-33a-5p ; hsa-mir-301a-3p ; hsa-mir-205-5p ; hsa-mir-183-5p ; hsa-mir-203a-5p
Nearest miRNA
hsa-mir-10392/Upstream/630988; hsa-let-7a-2/Downstream/3435848;
Nearest TSS
ENST00000527297/Upstream/4711; ENST00000525183/Downstream/13352;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/150293, chr11-CpG: 79/Downstream/198219
Nearest cancer related gene
UVRAG(TSG, No orient, 0)
Upstream sequence
gatgaattttgtcagatggtttttctatatccattgcaatgatcatatggttttttctttattctcttaatgtgattaactttttggtttattttcaaat
Downstream sequence
gtttaacattgcatttctggaataaacctaaattgattataatatataattatttttgtattttgttggatttattcttataaatttttttccttcgtat
Target sequence
aatgatcatatggttttttctttattctcttaatgtgattaactttttggtttattttcaaat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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