Basic Information
VIS ID
TVIS30014832
Fusion event
HIV-MAML2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
95712890/95979726 (Hg38)
End
95712854/95979726 (Hg38)
Orient
-
Location type
Exonic
Target gene
MAML2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-218-5p ; hsa-mir-6868-3p ; hsa-mir-6715b-3p ; hsa-mir-3605-3p ; hsa-mir-205-5p
Nearest miRNA
hsa-mir-10392/Upstream/1513146; hsa-let-7a-2/Downstream/361712;
Nearest TSS
ENST00000527297/Upstream/54411; ENST00000332349/Downstream/113794;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/55525, chr11-CpG: 75/Downstream/409646
Nearest cancer related gene
MAML2(OG, No orient, 0)
Upstream sequence
CCAACAGATCCAGCTCCAAAAGTGGCTACATTGTTATTATTACTTGGCCCTAAGGTAGGTGGCCGTGGCATCATAGGGTTGTTTTGATTTGCTAACAATT
Downstream sequence
GCTTTGGGTTTCTCTGTTGGGTCAATTGATTCATTCCTGAAGTGACACTGTATGTGTTAGGTTGATTACAAGGCAGATTTCCATACATCCCCATATTCTG
Target sequence
GTGGCATCATAGGGTTGTTTTGATTTGCTAACAATT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate