Basic Information
VIS ID
TVIS30014836
Fusion event
HIV-NPAT integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
108026849/108156122 (Hg38)
End
108026961/108156122 (Hg38)
Orient
+
Location type
Intronic
Target gene
NPAT
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-4765 ; hsa-mir-759 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5586-3p ; hsa-mir-3925-5p ; hsa-mir-4773 ; hsa-mir-4797-5p ; hsa-mir-595 ; hsa-mir-4796-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p
Nearest miRNA
hsa-mir-10392/Upstream/4306142; hsa-let-7a-2/Downstream/3191635;
Nearest TSS
ENST00000527297/Upstream/10001; ENST00000532931/Downstream/5561;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/34118, chr11-CpG: 75/Downstream/66362
Nearby gene
NPAT(No orient, 1269)
Upstream sequence
aggtacactaacttcttgatttggtaattctactctctaaaatttctaaggaaatagttaacataaacaaatgtttataaaaatgctcactgctgttttt
Downstream sequence
aggactgcttgagtccaagagtttgatatcatcctgggcaacatagtgagaccccatctctctgaaagacaaaaacaaaaaacaaaaaacaaaaaaacca
Target sequence
gtttgtaatagctaaaaaaaggaaaAAGCTTTATATTATTGGAAGTAAAAGCAGCAgctggatgaggtggctcacatgcctgtaatcccaacacctgggaggccgaggcagg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate