Basic Information
VIS ID
TVIS30014847
Fusion event
HIV-JAML integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118092928/118222213 (Hg38)
End
118092955/118222213 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
JAML
miRNAs that regulate target gene
hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-3124-3p ; hsa-mir-665 ; hsa-mir-4328 ; hsa-mir-873-5p
Nearest miRNA
hsa-mir-10392/Upstream/4772125; hsa-let-7a-2/Downstream/421787;
Nearest TSS
ENST00000527297/Upstream/7322; ENST00000529713/Downstream/1874;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/68734, chr11-CpG: 22/Downstream/137236
Nearby gene
MPZL3(No orient, 7407)
Upstream sequence
ttgttttaaaagcccctgctggccaggcacagtggcttatgcctataatcctagcactttgagaggccaaggtggacagatcgcttgagcccaggagttt
Downstream sequence
caccatctgaacaaaaaaaaaatacaaaaattagctggatgtagtggcaggcacctgtagtcctagctactcaggaggctgaagtgggaggatcacttga
Target sequence
gagaccagcctgagcaacttggtgaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate