Basic Information
VIS ID
TVIS30014848
Fusion event
HIV-MPZL3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118097865/118227150 (Hg38)
End
118097915/118227150 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
MPZL3
miRNAs that regulate target gene
hsa-mir-4436b-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-671-5p ; hsa-mir-4729 ; hsa-mir-4786-3p ; hsa-mir-449b-3p ; hsa-mir-1228-3p ; hsa-mir-1273g-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3612 ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-4459 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6807-5p ; hsa-mir-766-3p ; hsa-mir-7703
Nearest miRNA
hsa-mir-10392/Upstream/4777062; hsa-let-7a-2/Downstream/416850;
Nearest TSS
ENST00000527297/Upstream/2056; ENST00000529713/Downstream/25170;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/73671, chr11-CpG: 22/Downstream/132299
Nearby gene
MPZL3(No orient, 2470)
Upstream sequence
TCTCTTGAAGCACCAGTGCTGGGTTCAGGAGCTACAGAGGACTAAGATGTTCCCCAAGTAGCCTGAAGTAACAGGTCACATGGAAAACACAAAGCAATTG
Downstream sequence
AGTCATGTAACCACATGTAAAAACTTCAGCAGCTAAAGAAAAATTCTGGAAGGCTTTTAACCCCTTCTGAACTAAGTTCCCTTTCTAAACGAGGCTGGTT
Target sequence
GTGAGTCCACATTTTGTAATAGAATTAAGAGCGTAATGCATAAAACTTAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate