Basic Information
VIS ID
TVIS30014849
Fusion event
HIV-chr11 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118140542/118269827 (Hg38)
End
118140388/118269827 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11B
Nearest miRNA
hsa-mir-10392/Upstream/4819739; hsa-let-7a-2/Downstream/374173;
Nearest TSS
ENST00000527297/Upstream/5291; ENST00000529713/Downstream/34718;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/116348, chr11-CpG: 22/Downstream/89622
Nearby gene
MPZL2(No orient, 5291)
Upstream sequence
gaggccttgggaaggcttcccaaaacaggAACCATCCAGTGTAGCTGGCTAGCAGCTACAGGCTCTAGGGTGAGAGAAACATGGGTGTGAATCAAAGGTC
Downstream sequence
TACATCATTTATTCattcattcatttaagaaacacgttttgggtacctatgacatgccaggcattttcctgggcacacaaggaataaagtagtgaacaaa
Target sequence
caaatgagttgtgatcagagaaacacggaagccagggtccttcagccagccttggaggccttgggaaggcttcccaaaacaggAACCATCCAGTGTAGCTGGCTAGCAGCTACAGGCTCTAGGGTGAGAGAAACATGGGTGTGAATCAAAGGTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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