Basic Information
VIS ID
TVIS30014855
Fusion event
HIV-ARCN1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118451934/118581219 (Hg38)
End
118452205/118581219 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
ARCN1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-361-5p ; hsa-mir-130b-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-let-7b-5p ; hsa-mir-652-3p ; hsa-mir-193b-3p ; hsa-mir-30c-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-let-7e-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-1185-1-3p ; hsa-mir-770-5p ; hsa-mir-1185-2-3p
Nearest miRNA
hsa-mir-10392/Upstream/5131131; hsa-let-7a-2/Downstream/62781;
Nearest TSS
ENST00000527297/Upstream/8249; ENST00000525427/Downstream/25221;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/8303, chr11-CpG: 276/Downstream/26373
Upstream sequence
aaaaataaTACTACTACTAGTCATGTCACTAAATAAATATGTCATTCTATGGAACATTTCCTGAGATGCTGAGAAAACAGATGTGAAGAAATAATTAGTA
Downstream sequence
AAGGCTCTTCTCAAGAGTGGTAAGAGTACTGCTATAATACTGGGTTCCACTTTTTGTTTTACATTTTATGTGAAACTAGTTTTTCCTCCAAAGCAGCTGA
Target sequence
CTTACTTATGCATATGTTCCTGGCAGGTGCTGTTGGCAGCAGCGGTCTGCACAAAAGCAGGAAAGGCTATTGTTTCTCGACAGTTTGTGGAAATGACCCGAACTCGGATTGAGGGCTTATTAGCAGCTTTTCCAAAGCTCATGAACACTGGAAAACAACATACGTTTGTTGAAACAGAGAGTGTAAGATATGTCTACCAGCCTATGGAGAAACTGTATATGGTACTGATCACTACCAAAAACAGCAACATTTTAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate