Basic Information
VIS ID
TVIS30014857
Fusion event
HIV-DDX6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
End
118636784/118766174 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-130b-3p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-877-3p ; hsa-mir-505-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-145-5p ; hsa-mir-143-3p ; hsa-mir-218-5p ; hsa-mir-2909 ; hsa-mir-4477b ; hsa-mir-2053 ; hsa-mir-5089-3p ; hsa-mir-1296-5p ; hsa-mir-582-5p ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-548v ; hsa-mir-187-5p ; hsa-mir-139-5p ; hsa-mir-4277 ; hsa-mir-6834-3p ; hsa-mir-5584-3p ; hsa-mir-3158-3p ; hsa-mir-4446-3p ; hsa-mir-5088-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-759 ; hsa-mir-6868-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-3613-3p ; hsa-mir-6074 ; hsa-mir-548m ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-3681-3p ; hsa-mir-148a-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-19a-3p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-92a-2-5p ; hsa-mir-4525 ; hsa-mir-5010-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-3175 ; hsa-mir-6134 ; hsa-mir-6878-5p ; hsa-mir-558 ; hsa-mir-4311 ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-587 ; hsa-mir-302c-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-4540 ; hsa-mir-3124-3p ; hsa-mir-554 ; hsa-mir-6501-3p ; hsa-mir-6838-3p ; hsa-mir-646 ; hsa-mir-4520-3p ; hsa-mir-6882-3p ; hsa-mir-4638-3p ; hsa-mir-335-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-4272 ; hsa-mir-22-3p ; hsa-mir-3654 ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-4653-3p ; hsa-mir-3924 ; hsa-mir-130a-3p ; hsa-mir-28-3p ; hsa-mir-301a-3p ; hsa-mir-301b-3p ; hsa-mir-3666 ; hsa-mir-3688-5p ; hsa-mir-4295 ; hsa-mir-4302 ; hsa-mir-4524a-3p ; hsa-mir-454-3p ; hsa-mir-545-3p ; hsa-mir-644a ; hsa-mir-885-3p ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-10392/Upstream/122095; hsa-let-7a-2/Downstream/144534;
Nearest cancer related gene
DDX6(OG, No orient, 0)
Upstream sequence
taaaaaaaaagaaaagaaaCACTGCCCCTTATAATCTAGATACCGAGATGTATTAAAAAATTGGGCTGGGCAGCACAGTGAgtaactcatgcctagaatc
Downstream sequence
ccagcacttttggaggctgaggcaggaggatcgtttgagctcaggagtttaagaccagcctgggcaacatagcaagaccccatctctactaaaaaaaaaa
Target sequence
aaaaaaaagaaaagaaaCACTGCCCCTTATAATCTAGATACCGAGATGTATTAAAAAATTGGGCTGGGCAGCACAGTGAgtaactcatgcctagaatc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate