Basic Information
VIS ID
TVIS30014868
Fusion event
HIV-SORL1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
121398660/121527951 (Hg38)
End
121398356/121527951 (Hg38)
Orient
-
Location type
Intronic
Target gene
SORL1
miRNAs that regulate target gene
hsa-mir-127-5p ; hsa-mir-1229-3p
Nearest miRNA
hsa-mir-10392/Upstream/2214939; hsa-let-7a-2/Downstream/571806;
Nearest TSS
ENST00000527297/Upstream/74938; ENST00000524873/Downstream/27091;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/75358, chr11-CpG: 113/Downstream/1127619
Upstream sequence
ttctctatttttcgttcgtttaggtgtttcaatactgttgatctttccaaagaatctgcttttggctcttgttgattttctattgtctgttttctgtttt
Downstream sequence
gttgctttttttctttattattattttttcccttatttgttttgttgttctttttgtagcttattaagatataaccttgggttattgattttatatcttc
Target sequence
tttctctggttgatacaaggctattcagattttcttctttttgtttcaattttgatgagttgtgtgtttcaagaaatttgtcccttcatgtaagttgtgacatttgttggccttatgttatcaatgatatattctctttatctttttaatgtctgtaggatctttggtgatgatttcattcttgatattggtgatatgtgtattttctctatttttcgttcgtttaggtgtttcaatactgttgatctttccaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate