Basic Information
VIS ID
TVIS30014869
Fusion event
HIV-UBASH3B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
122562384/122691676 (Hg38)
End
122562450/122691676 (Hg38)
Orient
+
Location type
Intronic
Target gene
UBASH3B
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-200a-3p ; hsa-mir-491-3p ; hsa-mir-192-3p ; hsa-mir-1227-3p ; hsa-mir-4275 ; hsa-mir-586 ; hsa-mir-3662 ; hsa-mir-455-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-486-5p ; hsa-mir-4797-5p
Nearest miRNA
hsa-let-7a-2/Upstream/539368; hsa-mir-3167/Downstream/689764;
Nearest TSS
ENST00000527297/Upstream/35951; ENST00000526386/Downstream/17586;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/34905, chr11-CpG: 51/Downstream/191002
Upstream sequence
ATTTAAGGCTTAAAATCTTTATTGAAAAGTGTTTTTATTCAGCTTTCAAAGATACCAGTTCATCTGTTATTGCTGTAGCCACCCACCACTTGCGGGAAAA
Downstream sequence
GCCTGGCCTTCTGCTGGGTAGATGTGGAGCTGGTGATTTTGCTGAGTCCCCTGGCTTGAGCAAAAGGCTGTGATGGCCATTTGTGACGGGGTTCTGTGTT
Target sequence
TCCCAAAATGTGGGTATTTTACAAATGAAAAAGAGACATTTCTGGAATCAATGAAAAGGCTGCCTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate