Basic Information
VIS ID
TVIS30014871
Fusion event
HIV-CHEK1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
125502034/125632139 (Hg38)
End
125501999/125632139 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHEK1
miRNAs that regulate target gene
hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-193b-3p ; hsa-mir-24-3p ; hsa-mir-99b-5p ; hsa-mir-15b-5p ; hsa-mir-92a-3p ; hsa-mir-497-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-4672 ; hsa-mir-4789-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-383-3p ; hsa-mir-4524a-5p ; hsa-mir-4733-3p ; hsa-mir-4524b-5p ; hsa-mir-6074 ; hsa-mir-6838-5p ; hsa-mir-513b-3p ; hsa-mir-410-3p ; hsa-mir-26a-5p ; hsa-mir-8485 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-550b-2-5p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-7703 ; hsa-mir-1227-3p ; hsa-mir-139-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-323a-3p ; hsa-mir-197-3p ; hsa-mir-1226-3p ; hsa-mir-646 ; hsa-mir-6507-5p ; hsa-mir-505-3p
Nearest miRNA
hsa-let-7a-2/Upstream/2250627; hsa-mir-3167/Downstream/1356319;
Nearest TSS
ENST00000527297/Upstream/5390; ENST00000531062/Downstream/1148;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/6168, chr11-CpG: 105/Downstream/255021
Nearest cancer related gene
CHEK1(TSG, No orient, 0)
Upstream sequence
CTTCTATCAATTTGTGTAAAAGGCCAATATAAAAATTGCGTCATGCTATAATATTTTTTATGCTATAATATTTTTTATGCCATTAGCCTTTTTGTCCCAC
Downstream sequence
TTACACACTATTTCATGTTAGTATGTATAGATATACCTTGTTGATTGTTTTCAAAACCTACCTCCACATTTTCCATTGTACAAATTTGGACATTTATtta
Target sequence
TAATATTTTTTATGCCATTAGCCTTTTTGTCCCAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate