VISDB - VIS Detail

Basic Information

VIS ID

TVIS30014875

Fusion event

HIV-ETS1 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr11

Cytoband

q24.3

Reference genome

GRCh37/hg19

Start

128379483/128509588 (Hg38)

End

128379368/128509588 (Hg38)

Orient

Location type

Intronic

Target gene

ETS1

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-200b-3p ; hsa-mir-31-5p ; hsa-mir-155-5p ; hsa-mir-193b-3p ; hsa-mir-208a-3p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-125b-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-145-5p ; hsa-mir-200c-3p ; hsa-mir-1-3p ; hsa-mir-499a-5p ; hsa-mir-1202 ; hsa-mir-3972 ; hsa-mir-5006-5p ; hsa-mir-23b-3p ; hsa-mir-570-3p ; hsa-mir-584-3p ; hsa-mir-7852-3p ; hsa-mir-377-3p ; hsa-mir-5003-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-543 ; hsa-mir-4776-3p ; hsa-mir-1228-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-8064 ; hsa-mir-4643 ; hsa-mir-1825 ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-346 ; hsa-mir-2276-3p ; hsa-mir-4772-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-4328 ; hsa-mir-654-3p ; hsa-mir-506-3p ; hsa-mir-144-3p ; hsa-mir-199a-5p ; hsa-mir-324-5p

Nearest miRNA

hsa-let-7a-2/Upstream/1521046; hsa-mir-4697/Downstream/12802;

Nearest TSS

ENST00000527297/Upstream/4194; ENST00000525706/Downstream/12613;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/57588, chr11-CpG: 95/Downstream/12229

Nearest cancer related gene

ETS1(OG, No orient, 0)

Upstream sequence

GCTAGCCACCTTTCATGTGTCTACTTTGGATTTGAAAATGCACCATGGAAATCAGGTGAAAAttttttttttttttttttttttttttACTTTCCCACTA

Downstream sequence

CTAACACATCCCAATGGTAGATATGTATAAGTGAAATGAGTGCGTTCTTCCTGCCCCTATAATGACAAGCCTGACAGAGAACACATCACACAGAAGAATG

Target sequence

AGTTTAGTAAATTTGGCTAGCCACCTTTCATGTGTCTACTTTGGATTTGAAAATGCACCATGGAAATCAGGTGAAAAttttttttttttttttttttttttttACTTTCCCACTA

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.