Basic Information
VIS ID
TVIS30014877
Fusion event
HIV-FLI1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
128571108/128701213 (Hg38)
End
128571066/128701213 (Hg38)
Orient
-
Location type
Intronic
Target gene
FLI1
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-155-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-let-7a-2/Upstream/178764; hsa-mir-4697/Downstream/1965522;
Nearest TSS
ENST00000527297/Upstream/5190; ENST00000608055/Downstream/56893;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/6043, chr11-CpG: 16/Downstream/109224
Nearest cancer related gene
FLI1(OG, No orient, 0)
Upstream sequence
TCTTCAAAGACACCTGTTGATTAAATATGGCATTAGGGGAGGGAGGAGAAACTCTATTTCACCAGATGACATAAAACTGTGATTATCCTTCTCATCCCTT
Downstream sequence
CCTTCCCAGGGGATTTCACCATGAGCAATCTTTTCAATTGGGCCTTCTATCCTGGGCTACAATTTTAGTTCCTTTTGAGAATGAGTCAGCAGATAGTGCT
Target sequence
TCACCAGATGACATAAAACTGTGATTATCCTTCTCATCCCTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate