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TVIS30014878
Basic Information
VIS ID
TVIS30014878
Fusion event
HIV-KDM5A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
427700/318534 (Hg38)
End
427948/318534 (Hg38)
Orient
+
Location type
Intronic
Target gene
KDM5A
miRNAs that regulate target gene
hsa-mir-335-5p
;
hsa-mir-130b-5p
;
hsa-mir-517-5p
;
hsa-mir-5684
;
hsa-mir-136-5p
;
hsa-mir-526a
;
hsa-mir-523-5p
;
hsa-mir-522-5p
;
hsa-mir-520c-5p
;
hsa-mir-519c-5p
;
hsa-mir-519b-5p
;
hsa-mir-519a-5p
;
hsa-mir-518f-5p
;
hsa-mir-518e-5p
;
hsa-mir-518d-5p
;
hsa-mir-4662a-5p
;
hsa-mir-539-5p
;
hsa-mir-520g-5p
;
hsa-mir-3123
;
hsa-mir-3925-5p
;
hsa-mir-4797-5p
;
hsa-mir-618
;
hsa-mir-4284
;
hsa-mir-4772-3p
;
hsa-mir-4638-5p
;
hsa-mir-1307-3p
;
hsa-mir-1304-3p
;
hsa-mir-6741-3p
;
hsa-mir-4485-5p
;
hsa-mir-6890-3p
;
hsa-mir-4655-5p
;
hsa-mir-559
;
hsa-mir-548y
;
hsa-mir-548w
;
hsa-mir-548o-5p
;
hsa-mir-548j-5p
;
hsa-mir-548i
;
hsa-mir-548h-5p
;
hsa-mir-548d-5p
;
hsa-mir-548c-5p
;
hsa-mir-548bb-5p
;
hsa-mir-548b-5p
;
hsa-mir-548ay-5p
;
hsa-mir-548au-5p
;
hsa-mir-548as-5p
;
hsa-mir-548ar-5p
;
hsa-mir-548aq-5p
;
hsa-mir-548ap-5p
;
hsa-mir-548am-5p
;
hsa-mir-548ak
;
hsa-mir-548ae-5p
;
hsa-mir-548ad-5p
;
hsa-mir-548ab
;
hsa-mir-548a-5p
;
hsa-mir-548n
;
hsa-mir-548x-3p
;
hsa-mir-548j-3p
;
hsa-mir-548aq-3p
;
hsa-mir-548am-3p
;
hsa-mir-548aj-3p
;
hsa-mir-548ah-3p
;
hsa-mir-548ae-3p
;
hsa-mir-4634
;
hsa-mir-548z
;
hsa-mir-548h-3p
;
hsa-mir-548d-3p
;
hsa-mir-548bb-3p
;
hsa-mir-548ac
;
hsa-mir-96-5p
;
hsa-mir-1271-5p
;
hsa-mir-182-5p
;
hsa-mir-6809-3p
;
hsa-mir-7150
;
hsa-mir-4753-3p
;
hsa-mir-4778-3p
;
hsa-mir-136-3p
;
hsa-mir-181c-5p
;
hsa-mir-181d-5p
;
hsa-mir-181b-5p
;
hsa-mir-181a-5p
Nearest miRNA
hsa-let-7i/Downstream/1341781;
Nearest TSS
ENST00000382841/Upstream/7320;
ENST00000537453/Downstream/4620;
Nearest CpG islands
None/Target,
chr12-CpG: 104/Upstream/114369
,
chr12-CpG: 37/Downstream/70398
Nearest cancer related gene
KDM5A
(TSG, No orient, 0)
Upstream sequence
AAACTCTTCCACATCATCTAGCAGATTCTGAAAAGGTCAAAAGAAATAAAAATCAGAAAAACAAATTTAAAACATACAAAAGAGTATGAAATAGACATAG
Downstream sequence
atgcagatgaccagacagtgaacataggaataaaatgtttcagttagtgtcaagcgctctgaaaataaaatagggcagcacaacagagaatgaccagagt
Target sequence
TCAAGGCAAACTATCAATTCTAGACTCTTATAATCTCACCATCATAACACCAAATATTCAGATATGACAGTTAAATTAATAAATATGCTTTTGTGTAATTACTTCTAGCTATTCTCCTACTTTTAAAATATAGttgattcattcaataaatatttaatgactgctgacttagatgcaggcacttttctaggcacacagtattaaagaagacataaaatagtccttgtcttcagagaacatacattcta
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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