Basic Information
VIS ID
TVIS30014884
Fusion event
HIV-CD4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
6927712/6818546 (Hg38)
End
6927812/6818546 (Hg38)
Orient
+
Location type
Intronic
Target gene
CD4
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-3674 ; hsa-mir-7843-3p ; hsa-mir-877-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4470 ; hsa-mir-4731-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4786-3p ; hsa-mir-6784-5p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-4695-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-5197-5p ; hsa-mir-1273d ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-638 ; hsa-mir-4713-3p
Nearest miRNA
hsa-mir-3649/Upstream/5158166; hsa-let-7i/Downstream/145153;
Nearest TSS
ENST00000382841/Upstream/4492; ENST00000541431/Downstream/2999;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/44606, chr12-CpG: 23/Downstream/5564
Nearest cancer related gene
CD4(TSG, No orient, 0)
Upstream sequence
CAGCCAATGGCCCTGATTGTGCTGGGGGGCGTCGCCGGCCTCCTGCTTTTCATTGGGCTAGGCATCTTCTTCTGTGTCAGGTGCCGGCACCGAAGGGTGA
Downstream sequence
ACTCGTAAGTTCCCTTGCTGCCCTGTCCCAGATCCCACTCAAGGGAGAGACAGGAAGGAGCAGAGAGTTAATTCCAGGATAGATGGCCTGGGCCATGTAA
Target sequence
GTAACCCCACACCTGGTCCCCACAAGGCCCTCAAACCCCTGAGTCCTCTACCAGGAGATCCTGTATATGGGAACTGATTTTGGCCCAGCTCCCTCTGCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate