Basic Information
VIS ID
TVIS30014886
Fusion event
HIV-RIMKLB integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
8844917/8692321 (Hg38)
End
8845136/8692321 (Hg38)
Orient
+
Location type
Intronic
Target gene
RIMKLB
miRNAs that regulate target gene
hsa-mir-8066 ; hsa-mir-218-5p ; hsa-mir-1273e ; hsa-mir-636 ; hsa-mir-4480 ; hsa-mir-3691-3p ; hsa-mir-3184-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-6818-3p ; hsa-mir-6857-5p ; hsa-mir-653-3p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-513b-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-4450 ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-520f-5p ; hsa-mir-4323
Nearest miRNA
hsa-mir-141/Upstream/1728130; hsa-let-7i/Downstream/547146;
Nearest TSS
ENST00000382841/Upstream/10630; ENST00000539923/Downstream/4856;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/86838, chr12-CpG: 150/Downstream/5135
Nearby gene
RIMKLB(No orient, 5600)
Upstream sequence
taacaatatttgctcaaccttagaatgttgcttgaggctacaatgagtttataaatgttgagggctttaaataaagagcattttacaaatgGTTATTTTG
Downstream sequence
ATACAATTAAAGAAGTAGGGGGAAAACCTGTATCATGTTTCTTGCCAAGACTGTGTTTTCTTTCCACCCATTCTTTCTCTTCTGTGATTCAGCCAATGTA
Target sequence
GTCTCTAAGACACTGTGCTCAAACTTTCATGTGTCTAAAGATCATTTAGTATGCTTATTCCAAATGCAGATAAATTGCTGATTTTAGATGCTTTGAGTTGCTCAAGAAATGCAGGTACACAGGCTCATTCaggtcagaggcagaggtcaaggaatctgcattttaaacaagcattccaggtaatttctatgTGGTAGAGGAAAAAAAAATCTTAACCAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate