Basic Information
VIS ID
TVIS30014890
Fusion event
HIV-ETV6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12020890/11867956 (Hg38)
End
12020843/11867956 (Hg38)
Orient
-
Location type
Intronic
Target gene
ETV6
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-296-3p ; hsa-mir-99b-5p ; hsa-mir-92a-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-4712-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-3163 ; hsa-mir-1252-3p ; hsa-mir-3662 ; hsa-mir-574-5p ; hsa-mir-297 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-676-3p ; hsa-mir-135a-3p ; hsa-mir-4724-5p ; hsa-mir-6757-5p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-3157-5p ; hsa-mir-30a-3p ; hsa-mir-4691-3p ; hsa-mir-153-5p ; hsa-mir-4422 ; hsa-mir-548e-5p ; hsa-mir-335-3p ; hsa-mir-3667-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2628405; hsa-let-7i/Downstream/243996;
Nearest TSS
ENST00000382841/Upstream/115455; ENST00000266427/Downstream/17981;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/218337, chr12-CpG: 102/Downstream/398789
Nearest cancer related gene
ETV6(OG, No orient, 0)
Upstream sequence
GGAGCCGTGTAGAAATCCCCATTTTTATGGGCAGATTTCTGTCCTTCTGCACCTTAGCAGGGACTTCTGGAGCCAGGTGTGTGCCGGTCCATTCCCCGAC
Downstream sequence
CCAGCCCTCAGAGCTACTTCTCTTGCTGAGCTGTGTACACTTCTGATGTTATCCTCGCTCACATGTCACCAGCTTGCAACTTTGAGTGGGATGAGTTAGA
Target sequence
TTAGCAGGGACTTCTGGAGCCAGGTGTGTGCCGGTCCATTCCCCGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate