Basic Information
VIS ID
TVIS30014891
Fusion event
HIV-LRP6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12311516/12158582 (Hg38)
End
12311495/12158582 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRP6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7-5p ; hsa-mir-940 ; hsa-mir-628-3p ; hsa-mir-221-3p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-mir-183-5p ; hsa-mir-95-5p ; hsa-mir-202-3p ; hsa-mir-126-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-7158-5p ; hsa-mir-3124-3p ; hsa-mir-5571-5p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-8485 ; hsa-mir-8064 ; hsa-mir-6844 ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-5092 ; hsa-mir-21-5p ; hsa-mir-29c-3p ; hsa-mir-29b-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/46546; hsa-let-7i/Downstream/606067;
Nearest TSS
ENST00000382841/Upstream/23354; ENST00000543990/Downstream/44741;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/508963, chr12-CpG: 102/Downstream/108163
Upstream sequence
tctggctaatttttttattttttgtagaggcaaggtctcgctatattgcctaggctggtcttgaactcctgagctgaagcattcctcccacctcagcttc
Downstream sequence
ccaaagtgctgggttacggacataagacaATGGACCAGCATAAGACTTAATTTTTCTATAACATCAAATTGCTATCATCAAACAAGTAATAAGTAACAAA
Target sequence
cattcctcccacctcagcttc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate