Basic Information
VIS ID
TVIS30014893
Fusion event
HIV-BORCS5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12605917/12452983 (Hg38)
End
12605767/12452983 (Hg38)
Orient
-
Location type
Intronic
Target gene
BORCS5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4474-3p ; hsa-mir-7108-5p ; hsa-mir-6870-3p ; hsa-mir-205-5p ; hsa-mir-6793-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-6729-3p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-640 ; hsa-mir-1299 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-3653-5p ; hsa-mir-6777-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-4725-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/340947; hsa-let-7i/Downstream/311666;
Nearest TSS
ENST00000382841/Upstream/95565; ENST00000544086/Downstream/32370;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/95489, chr12-CpG: 111/Downstream/108716
Upstream sequence
TGTCTGAATCTCTACTGCAGGTCAAGTAGCCATGGTCTGGTGGGGATAGAGGTGGCAGGTGGGCTAGAACGTGCCATATCTTGATTTGTGGCAATGGGCC
Downstream sequence
TCCTACTCTTCGGAGTGGAGACAGCTAATACCATGAGTCAAAGACCAAATCGGGATAGCCGATGTATAAAAACACAAGCACCGGGTTTGCAaactggaag
Target sequence
TGACCCTGAAAGGTTTTGTTGCAGCCTGTCATACCCTAACCTTTATAATCTGTCTGAATCTCTACTGCAGGTCAAGTAGCCATGGTCTGGTGGGGATAGAGGTGGCAGGTGGGCTAGAACGTGCCATATCTTGATTTGTGGCAATGGGCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate