Basic Information
VIS ID
TVIS30014898
Fusion event
HIV-CDKN1B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.1
Reference genome
End
12874051/12721325 (Hg38)
Orient
-
Location type
Exonic
Target gene
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-181a-5p ; hsa-mir-24-3p ; hsa-mir-192-5p ; hsa-mir-196a-5p ; hsa-mir-190a-5p ; hsa-mir-218-5p ; hsa-mir-128b ; hsa-mir-98-5p ; hsa-mir-1260b ; hsa-mir-148a-3p ; hsa-mir-194-5p ; hsa-mir-182-5p ; hsa-mir-200b-3p ; hsa-mir-452-5p ; hsa-mir-2355-5p ; hsa-mir-548v ; hsa-mir-187-5p ; hsa-mir-6793-3p ; hsa-mir-186-3p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-561-3p ; hsa-mir-548m ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-455-5p ; hsa-mir-4789-5p ; hsa-mir-4672 ; hsa-mir-6768-5p ; hsa-mir-3148 ; hsa-mir-651-3p ; hsa-mir-196b-5p ; hsa-mir-3658 ; hsa-mir-1303 ; hsa-mir-448 ; hsa-mir-5696 ; hsa-mir-153-3p ; hsa-mir-6866-5p ; hsa-mir-155-5p ; hsa-mir-1909-5p ; hsa-mir-1827 ; hsa-mir-4729 ; hsa-mir-1288-5p ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-5694 ; hsa-mir-302f ; hsa-mir-877-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3591-5p ; hsa-mir-4276 ; hsa-mir-5701 ; hsa-mir-4255 ; hsa-mir-590-3p ; hsa-mir-4282 ; hsa-mir-142-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-3147 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-5191 ; hsa-mir-3140-3p ; hsa-mir-3616-3p ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-329-5p ; hsa-mir-4464 ; hsa-mir-4748 ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-4463 ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6734-3p ; hsa-mir-5088-3p ; hsa-mir-3912-5p ; hsa-mir-5581-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-219b-5p ; hsa-mir-8060 ; hsa-mir-1265 ; hsa-mir-4700-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-4742-5p ; hsa-mir-7852-3p ; hsa-mir-7151-5p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-4676-3p ; hsa-mir-892c-3p ; hsa-mir-148a-5p ; hsa-mir-221-5p ; hsa-mir-323a-3p ; hsa-mir-203a-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/609289; hsa-let-7i/Downstream/43324;
Nearest cancer related gene
CDKN1B(TSG, No orient, 0)
Upstream sequence
GGATGTAGCATTATGCAATTAGGTTTTTCCTTATTTGCTTCATTGTACTACCTGTGTATATAGTTTTTACCTTTTATGTAGCACATAAACTTTGGGGAAG
Downstream sequence
GGAGGGCAGGGTGGGGCTGAGGAACTGACGTGGAGCGGGGTATGAAGAGCTTGCTTTGATTTACAGCAAGTAGATAAATATTTGACTTGCATGAAGAGAA
Target sequence
CATATCGCTGACTTCATGGAATGGACATCCTGTATAAGCACTGAAAAACAACAACACAATAACACTAAAATTTTAGGCACTCTTAAATGATCTGCCTCTAAAAGCGTTGGATGTAGCATTATGCAATTAGGTTTTTCCTTATTTGCTTCATTGTACTACCTGTGTATATAGTTTTTACCTTTTATGTAGCACATAAACTTTGGGGAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate