Basic Information
VIS ID
TVIS30014907
Fusion event
HIV-WBP11 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
14946436/14793502 (Hg38)
End
14946737/14793502 (Hg38)
Orient
+
Location type
Intronic
Target gene
WBP11
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-877-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-mir-5093 ; hsa-mir-188-3p ; hsa-mir-4312 ; hsa-mir-643 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4496 ; hsa-mir-496 ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-1285-3p ; hsa-mir-136-5p ; hsa-mir-196a-3p ; hsa-mir-3187-5p ; hsa-mir-4421 ; hsa-mir-4797-5p ; hsa-mir-5189-5p ; hsa-mir-5687 ; hsa-mir-5699-3p ; hsa-mir-612 ; hsa-mir-649 ; hsa-mir-661 ; hsa-mir-6860 ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/1877584; hsa-let-7i/Downstream/2879797;
Nearest TSS
ENST00000382841/Upstream/18920; ENST00000330828/Downstream/7926;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/18413, chr12-CpG: 38/Downstream/9555
Upstream sequence
TGTTTTTCTTAATATGGCTACTCTCCTTTCTTTCCTGTAACATACCCATAATACGTTTATGCTGTTGAATAGTTATACCTTTTACCCCAAAGTGAACTTT
Downstream sequence
ATCTGATTTGTCGGTGTCACTGTCATCAGTACTGTCATCATGCTTATCTTGATCCATGTCCTCAGGATAGCCATCATCTTCACTGGTGCTAGAAACATCA
Target sequence
ATTACATAGACATTTTTATTACATACAGTTTAATGCTTTTCCTCataaacatccactgagtacttactgtgtCAAAAACTTTCAAAATTTTAATATATAAGATGAACACAGCTATGATCCCGACTTCCAAAGATTTCAGAGTACTCTCACAGATTCATTAATAAATTAGGACCTTCAGCTTGTTTTCTCTTTATTGATCAATACCATGAATCCTTCATCTGCACATACCTGACTTCTTTTCTTCATTGTTGTCTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate