Basic Information
VIS ID
TVIS30014915
Fusion event
HIV-NELL2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
44932819/44539036 (Hg38)
End
44932794/44539036 (Hg38)
Orient
-
Location type
Intronic
Target gene
NELL2
miRNAs that regulate target gene
hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-769-5p ; hsa-mir-3185 ; hsa-mir-4307 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-6507-5p ; hsa-mir-5571-3p ; hsa-mir-4266 ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-6729-3p ; hsa-mir-4779 ; hsa-mir-4695-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2215177; hsa-let-7i/Downstream/2648776;
Nearest TSS
ENST00000382841/Upstream/6415; ENST00000548424/Downstream/164744;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/702675, chr12-CpG: 86/Downstream/337011
Upstream sequence
gtttttcctattgactaaaatgttctttttctcatcctctcacctgagttagttaactatttctcatctatctgtcccatactaaaattaatgttccttg
Downstream sequence
gggaagctttcctggactccagagactatatttgatctcctATTACTTAATGATTTGTCTGTTTCCCCCCATATTCTCCTCGTATTTTGTATCCTTGTAA
Target sequence
cccatactaaaattaatgttccttg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate