Basic Information
VIS ID
TVIS30014927
Fusion event
HIV-chr12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
48216328/47822545 (Hg38)
End
48215862/47822545 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/458276; hsa-let-7i/Downstream/310252;
Nearest TSS
ENST00000382841/Upstream/1933; ENST00000550684/Downstream/4309;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/2140, chr12-CpG: 69/Downstream/82317
Nearby gene
HDAC7(No orient, 2565)
Upstream sequence
ATCTCCCTGCCTGTCTGTCCACACAGTGCCCAACATGTGGCTTTCTACACACCAGGACTCACTGCCTCCAACATATAGTCAGAGAAAAAGACAGCATGTG
Downstream sequence
CAACCTGCATCTGGGAAAGCTGGACTGTGTCTCTCCTTCCCCTGCCAGATTTACTTACCAGACCCCGCCTCATGGCAGAGTCCTAAGCCAGTTTCTAAGT
Target sequence
ATAACTACCCATGCTGACTCTCCAAGACACATGCTGTTCCACCTTAGGTATGTCATCCCCAGCCCTCAATTCCAAGCCAGATCATCCTCCTTCCAAATGCCTCTTTGGTGTCCACAGACTCCAGAAAAACTGCTTGGTTACTGCAGACCCCCAGCGACATGCCTGCTATCTCCCTTGTCTAGCTCCACAATTGATCCCAACCCCCAACACACACATATCCGTAGCTTTTCTGTAGCTATTTCTGTAGTAAAGCCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate