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TVIS30014930
Basic Information
VIS ID
TVIS30014930
Fusion event
HIV-LIMA1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
50581250/50187467 (Hg38)
End
50581379/50187467 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
LIMA1
miRNAs that regulate target gene
hsa-mir-130b-3p
;
hsa-mir-93-5p
;
hsa-mir-33a-5p
;
hsa-mir-27a-3p
;
hsa-mir-877-3p
;
hsa-mir-339-5p
;
hsa-mir-365a-3p
;
hsa-mir-186-5p
;
hsa-mir-10a-5p
;
hsa-mir-30c-5p
;
hsa-mir-16-5p
;
hsa-mir-4775
;
hsa-mir-190a-3p
;
hsa-mir-5011-5p
;
hsa-mir-875-5p
;
hsa-mir-20a-5p
;
hsa-mir-106b-5p
;
hsa-mir-499a-3p
;
hsa-mir-670-3p
;
hsa-mir-6891-3p
;
hsa-mir-6072
;
hsa-mir-3074-3p
;
hsa-mir-451b
;
hsa-mir-3120-3p
;
hsa-mir-3152-5p
;
hsa-mir-6805-3p
;
hsa-mir-5691
;
hsa-mir-6836-3p
;
hsa-mir-3144-3p
;
hsa-mir-4777-3p
;
hsa-mir-3613-5p
;
hsa-mir-496
;
hsa-mir-3194-3p
;
hsa-mir-367-5p
;
hsa-mir-1267
;
hsa-mir-616-5p
;
hsa-mir-373-5p
;
hsa-mir-371b-5p
;
hsa-mir-3613-3p
;
hsa-mir-520e
;
hsa-mir-520d-3p
;
hsa-mir-520c-3p
;
hsa-mir-520b
;
hsa-mir-520a-3p
;
hsa-mir-373-3p
;
hsa-mir-372-3p
;
hsa-mir-302e
;
hsa-mir-302d-3p
;
hsa-mir-302c-3p
;
hsa-mir-302b-3p
;
hsa-mir-302a-3p
;
hsa-mir-548t-5p
;
hsa-mir-548az-5p
;
hsa-mir-106a-5p
;
hsa-mir-526b-3p
;
hsa-mir-519d-3p
;
hsa-mir-20b-5p
;
hsa-mir-17-5p
;
hsa-mir-5096
;
hsa-mir-29b-2-5p
;
hsa-mir-6802-3p
;
hsa-mir-299-5p
;
hsa-mir-6814-5p
;
hsa-mir-3620-3p
;
hsa-mir-6865-3p
;
hsa-mir-4259
;
hsa-mir-4715-5p
;
hsa-mir-6768-3p
;
hsa-mir-519c-3p
;
hsa-mir-519b-3p
;
hsa-mir-519a-3p
;
hsa-mir-4796-3p
;
hsa-mir-3609
;
hsa-mir-548ah-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/1415430; hsa-let-7i/Downstream/46675;
Nearest TSS
ENST00000382841/Upstream/5288;
ENST00000551284/Downstream/8580;
Nearest CpG islands
None/Target,
chr12-CpG: 104/Upstream/19864
,
chr12-CpG: 38/Downstream/96004
Nearest cancer related gene
LIMA1
(TSG, No orient, 0)
Upstream sequence
AAATGCCTTTCATTCCTTCCAATTTGTGTAAAATATCTAGGTAATGAAACTGAAATTCTTCACCACACAGCAAATGGTTGGGCCAGCCCTGTGCAGCCTT
Downstream sequence
AAAAGATTCTAGACACTCTTCTAGCATAATTTTGACAGCTTTGCAAGCCAGCATAAAACCTCCCACTGTGTCTTCAGGGGGAGGAACAGCTGGCAGGGTA
Target sequence
AACCCTTCCTCTAATTTTCTGTGAAACTCTATGAAAGCATTTTGGGGAATATTCATATCTTAAATAGAGTGCTCTACACAGAGAAGAAAGGACAGTCCTCTGAAAAGGCAGTAATAGTGAGTGAGTGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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