Basic Information
VIS ID
TVIS30014939
Fusion event
HIV-ITGA5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
54810603/54416819 (Hg38)
End
54810648/54416819 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
ITGA5
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-31-5p ; hsa-mir-148b-3p ; hsa-mir-98-5p ; hsa-mir-1229-3p ; hsa-mir-484 ; hsa-mir-183-5p ; hsa-mir-152-3p ; hsa-mir-148a-3p ; hsa-mir-205-5p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-222-5p ; hsa-mir-6846-3p ; hsa-mir-5585-5p ; hsa-mir-4667-3p ; hsa-mir-6887-3p ; hsa-mir-383-3p ; hsa-mir-3065-3p ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-26a-5p ; hsa-mir-17-3p ; hsa-mir-330-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/79505; hsa-let-7i/Downstream/2777685;
Nearest TSS
ENST00000382841/Upstream/3391; ENST00000548617/Downstream/2308;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/37614, chr12-CpG: 21/Downstream/2332
Nearest cancer related gene
ITGA5(TSG, No orient, 0)
Upstream sequence
ccaagagcttaaatacctctccctaggtactagggtaccacgcaaaaaactagtaagtagtggggactcacacctacctctgtctgactgaaagctttgc
Downstream sequence
TACTATTTTGGTGTTCACCACAAGAGGTGATGCAGGAAGAACAAGAACACTGAGGCTCTCCCTCTTTGGCAATGGCTGTAGGTGAGGGGCTGTGTTTGTC
Target sequence
cctttccTACCATCTAACTGCTTTGGTGCTCGCCCTGTCCTTTAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate