Basic Information
VIS ID
TVIS30014955
Fusion event
HIV-NEMP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57466275/57072492 (Hg38)
End
57466301/57072492 (Hg38)
Orient
+
Location type
Intronic
Target gene
NEMP1
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-192-5p ; hsa-mir-24-3p ; hsa-let-7d-5p ; hsa-mir-93-3p ; hsa-mir-155-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/2735178; hsa-let-7i/Downstream/122012;
Nearest TSS
ENST00000382841/Upstream/21294; ENST00000555857/Downstream/6271;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/65804, chr12-CpG: 29/Downstream/5999
Upstream sequence
tggtgccactgcactccagcctgggcgacagagggagactctgcctcaaaaaataaaaaataaaaataaaaaaagaaAGAGGGGTATGTGTGCGTGCACA
Downstream sequence
GAAAACAAAGCAGTTTCTTTGGGAAAAGGAGGGAGGAGGAAAGAAGTTTACCTTAGAATACCGTAATCTACTTGAGGGAGCAGAGAGGAATACAAAGTAG
Target sequence
CACACATACTGCAAAATGAAGGACAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate