Basic Information
VIS ID
TVIS30014962
Fusion event
HIV-MARS integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57898833/57505050 (Hg38)
End
57898939/57505050 (Hg38)
Orient
+
Location type
Intronic
Target gene
MARS
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-505-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-339-5p ; hsa-mir-185-5p ; hsa-mir-222-3p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-541-5p
Nearest miRNA
hsa-mir-1228/Upstream/310474; hsa-let-7i/Downstream/7638;
Nearest TSS
ENST00000382841/Upstream/1064; ENST00000548630/Downstream/6536;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/16798, chr12-CpG: 19/Downstream/14974
Upstream sequence
ggctcagcctcccaaagtgctgggattacaggtgtgagccaccgcactgggccacctgactaatttttaaaatgcttttgtagagatgggttctcactgt
Downstream sequence
CTGAtttgttttttttttttttgagatggagcttctctcttgttgcccacactggagtgcaatggcacggtctcggctcactgcaacctctgcctcccag
Target sequence
gttacccaggctggtgtcaaactcttgggctcaagcagttctcctgcctctgcctgcaaacgtgttgggattagaggcatgagcaactgtgtccagcATTGACCTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate