Basic Information
VIS ID
TVIS30014966
Fusion event
HIV-RXYLT1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
64186554/63792774 (Hg38)
End
64186440/63792774 (Hg38)
Orient
-
Location type
Intronic
Target gene
RXYLT1
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-let-7i/Upstream/1189005; hsa-mir-10527/Downstream/30889;
Nearest TSS
ENST00000382841/Upstream/7804; ENST00000433461/Downstream/2944;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/12316, chr12-CpG: 45/Downstream/28945
Upstream sequence
gggcttttacagatattagctcagtgaattttaatcctcagaaccaccctgtgcagctggtggtattactcccattttgcaatgaaaaccttgatgttct
Downstream sequence
gagagattaaatgactAGTAAAGATGGGATTGAACCATGGTCCTCCCTTTAACATGATAGATTAGTCCACATCATCTACAAGTCACCTCCAATATTAAGT
Target sequence
ttgctgtgttccaggggcttttacagatattagctcagtgaattttaatcctcagaaccaccctgtgcagctggtggtattactcccattttgcaatgaaaaccttgatgttct
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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