Basic Information
VIS ID
TVIS30014967
Fusion event
HIV-LEMD3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
65582596/65188816 (Hg38)
End
65582203/65188816 (Hg38)
Orient
-
Location type
Intronic
Target gene
LEMD3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-22-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-let-7i/Upstream/566211; hsa-mir-1178/Downstream/834804;
Nearest TSS
ENST00000382841/Upstream/19233; ENST00000542032/Downstream/51750;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/18200, chr12-CpG: 88/Downstream/89790
Upstream sequence
accattatagtgacttacttggtctcagtatggaatacaaaagtcatgatgtcaggctcatggaagaagtattcctttcttgttcatcttatttttgttg
Downstream sequence
ctctaattgcagtgagaccatttggcatattgctgatggctgcaaacattcatttaagacactagaaagaatacagtgcaccagggagatgacaatgggc
Target sequence
aagcagtgatgggcagtgagcttttataggctgaatgtggaagtaaGACAAAACATAagtggaaaggccctagttagaagttagttggtggtttctgattgggtatgcttaagttttgttttactgtttacacgggattgggttttggtttgcttacagaggagttctgttcacagagaaaatcttcaggctaatggcttcctccttacttgctttaacaattttctccttttgtcagcctctccatcttgagtg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate