Basic Information
VIS ID
TVIS30014970
Fusion event
HIV-HELB integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
66709123/66315343 (Hg38)
End
66709064/66315343 (Hg38)
Orient
-
Location type
Exonic
Target gene
HELB
Nearest miRNA
hsa-let-7i/Upstream/64186; hsa-mir-1178/Downstream/2957814;
Nearest TSS
ENST00000382841/Upstream/12763; ENST00000536862/Downstream/6059;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/79719, chr12-CpG: 105/Downstream/753547
Upstream sequence
GACATTAGACAGTTACCCAGTATTGAACCTGGTAACTTGCTGAAAGATCTTTTTGAGACTCTTAAGTCAAGAAATTGTGCTATTGAGCTAAAGACAAACC
Downstream sequence
ATAGAGCAGAATCTCAGCTCATTGTGGACAATGCTACAAGGTATAATATTACTAAGAGTTTGCATTTTCTGTCTGTTGTATTAGAAATTTAAAAAATGGC
Target sequence
GAAAGATCTTTTTGAGACTCTTAAGTCAAGAAATTGTGCTATTGAGCTAAAGACAAACC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate