Basic Information
VIS ID
TVIS30014971
Fusion event
HIV-CCT2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
69991964/69598184 (Hg38)
End
69991919/69598184 (Hg38)
Orient
-
Location type
Intronic
Target gene
CCT2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-193b-3p ; hsa-mir-144-3p ; hsa-mir-539-5p ; hsa-mir-607 ; hsa-mir-3646 ; hsa-mir-3671 ; hsa-mir-5680 ; hsa-mir-4712-3p ; hsa-mir-5700
Nearest miRNA
hsa-let-7i/Upstream/13361; hsa-mir-1178/Downstream/9821073;
Nearest TSS
ENST00000382841/Upstream/5647; ENST00000550653/Downstream/1530;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/12240, chr12-CpG: 139/Downstream/140376
Upstream sequence
AATGAGAGATCCGAACTTAAGTTTTGTGGTTATTGATAGTTTTAAAATGAGTAGAAAATGAACTGGTTAATACTGCTTTTAAATTTGATTCTGGAGTTTC
Downstream sequence
TCCTCTTCGTGAGCAGTAACTGAAGCAGATTTTACATTGTTCCTAAATGTATAATTTTAAAAAGCTATCCTAGTTAGGAGTAAATCAGTGGTTCTTACAG
Target sequence
AAATGAACTGGTTAATACTGCTTTTAAATTTGATTCTGGAGTTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate