Basic Information
VIS ID
TVIS30014974
Fusion event
HIV-PPP1R12A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
80220397/79826617 (Hg38)
End
80220465/79826617 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPP1R12A
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-96-5p ; hsa-mir-30a-5p ; hsa-mir-93-3p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-448 ; hsa-mir-5007-3p ; hsa-mir-1179 ; hsa-mir-5700 ; hsa-mir-7150 ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-3616-3p ; hsa-mir-4645-3p ; hsa-mir-4761-3p ; hsa-mir-3662 ; hsa-mir-182-5p ; hsa-mir-1271-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p
Nearest miRNA
hsa-let-7i/Upstream/407296; hsa-mir-1178/Downstream/1005916;
Nearest TSS
ENST00000382841/Upstream/2839; ENST00000643417/Downstream/5979;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/135243, chr12-CpG: 76/Downstream/108017
Upstream sequence
TATCACATAAAGATCTACTGAAATATCGAATGACAGATAAGGAGTAAATAAAATTTAGAGTGACATAAGGAGCTGCTACTATAGTAATTTTTTAAAAAAG
Downstream sequence
TAGGAATTAGACAATTGTTGGCCAGATGCCAATAAAATGATTTTTCTCATGCATACAATATATTGTGTATGTTTCACTAGAATACTGATTCAGTAGGGGA
Target sequence
GATATAAGGCAAAATAATTTTACATGCACTCCTTCTCTGATAGCAAAATTATGATAAATTGTATAGCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate