Basic Information
VIS ID
TVIS30014975
Fusion event
HIV-chr12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
92219270/91825494 (Hg38)
End
92219305/91825494 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/5080345; hsa-mir-1178/Downstream/2736295;
Nearest TSS
ENST00000382841/Upstream/145363; ENST00000546710/Downstream/51897;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/871175, chr12-CpG: 128/Downstream/319440
Nearby gene
BTG1(No orient, 314783)
Upstream sequence
TACTGCACATAAATATCCACAATATACAGGCAGAATTCTTGATGCTGAGAGCTGTTAGCATAAAATCACATAACCAGGGACATTTCAGATTCATGGTCTC
Downstream sequence
CTCCTCCTCCCTCACCCTTAGTTATGGATGTTATATTCTATTTGATTAAAATGAGACCATAGAACAAAAGTTCCTTCCACCTTTATCTCCTAGTGCTTTG
Target sequence
CAATCTCAGTTGTTGCCAGGCTACATTTCTCTTGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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