Basic Information
VIS ID
TVIS30014982
Fusion event
HIV-TMEM263 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
107353077/106959299 (Hg38)
End
107353011/106959299 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM263
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-124-3p ; hsa-mir-218-2-3p ; hsa-mir-340-5p ; hsa-mir-487a-5p ; hsa-mir-487b-5p ; hsa-mir-584-5p ; hsa-mir-6878-3p ; hsa-mir-758-5p
Nearest miRNA
hsa-let-7i/Upstream/2367583; hsa-mir-1178/Downstream/1676511;
Nearest TSS
ENST00000382841/Upstream/2514; ENST00000551813/Downstream/7636;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/2988, chr12-CpG: 46/Downstream/27481
Upstream sequence
ATTTTAATGTATTACTTAAGGGTAACATTTAAAAATGGTCATTTTGAAttttttcttttttgatatggagtcttgctctgtcgcccaggctggagtgcag
Downstream sequence
tggcttgatctccactcactgcaacatccgtctcccaggttcaagagattttcctgcctcagcctccctggtagctgggattacaggtacccgccaccac
Target sequence
ATGGTCATTTTGAAttttttcttttttgatatggagtcttgctctgtcgcccaggctggagtgcag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate