Basic Information
VIS ID
TVIS30014990
Fusion event
HIV-NAA25 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
112478424/112040620 (Hg38)
End
112478354/112040620 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
NAA25
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-16-5p ; hsa-mir-155-5p ; hsa-mir-30b-5p ; hsa-mir-92a-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-6716-5p ; hsa-mir-3140-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-5002-5p ; hsa-mir-5571-5p ; hsa-mir-3908 ; hsa-mir-4506 ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-195-5p ; hsa-mir-552-5p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-6507-5p ; hsa-mir-6516-3p
Nearest miRNA
hsa-let-7i/Upstream/2905; hsa-mir-1178/Downstream/122638;
Nearest TSS
ENST00000382841/Upstream/5215; ENST00000551125/Downstream/1691;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/26568, chr12-CpG: 56/Downstream/67723
Upstream sequence
GTTTTCAAGTTACCATCTTTAACTTCTAAGAGGTCACCTTTACATTTACTGAAGACATCTGAAAACAAAAAACATTTTAGTTTTATTCAGCTTTTGTTTC
Downstream sequence
AATGCTATTTTAAGGAACACAACACACAAATAAAGAATAAGCAAATAAAAATTTAATTTAGAAAGCTATTTGTTTTTCATTTTCCATAATGAACCAAACT
Target sequence
AGGTCACCTTTACATTTACTGAAGACATCTGAAAACAAAAAACATTTTAGTTTTATTCAGCTTTTGTTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate