Basic Information
VIS ID
TVIS30014992
Fusion event
HIV-HECTD4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
112652549/112214745 (Hg38)
End
112652586/112214745 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
HECTD4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-296-3p ; hsa-mir-149-5p
Nearest miRNA
hsa-let-7i/Upstream/51424; hsa-mir-1178/Downstream/480289;
Nearest TSS
ENST00000382841/Upstream/13307; ENST00000547401/Downstream/4835;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/29734, chr12-CpG: 17/Downstream/166490
Upstream sequence
AAACAACAAATACAGCAACAAGGAAATAAAAACACTGAAAACGCTCCCCCAGCCTACCACCCACCCCCTGACATACACCCTTTTGTGCTGAAagcactta
Downstream sequence
tgaagtaagagaaaaatttttactttgccctgaaatgatttccaagtcatagtatgacttggcttgagtaaaaacactatgctgccaggggccgggtgtg
Target sequence
ggtaagtactctgctgagatgtctgagttatgctttg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate