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TVIS30014996
Basic Information
VIS ID
TVIS30014996
Fusion event
HIV-SPPL3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
121228486/120790683 (Hg38)
End
121228304/120790683 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
SPPL3
miRNAs that regulate target gene
hsa-mir-190a-3p
;
hsa-mir-5011-5p
;
hsa-mir-568
;
hsa-mir-21-5p
;
hsa-mir-653-3p
;
hsa-mir-4420
;
hsa-mir-181b-3p
;
hsa-mir-181b-2-3p
;
hsa-mir-6886-3p
;
hsa-mir-5189-3p
;
hsa-mir-938
;
hsa-mir-6780b-3p
;
hsa-mir-6890-3p
;
hsa-mir-6809-5p
;
hsa-mir-3613-3p
;
hsa-mir-605-5p
;
hsa-mir-4455
;
hsa-mir-6083
;
hsa-mir-1277-5p
;
hsa-mir-3924
;
hsa-mir-511-3p
;
hsa-mir-6867-5p
;
hsa-mir-5007-3p
;
hsa-mir-664a-3p
;
hsa-mir-3163
;
hsa-mir-1537-3p
;
hsa-mir-548ay-3p
;
hsa-mir-548at-3p
;
hsa-mir-548x-3p
;
hsa-mir-548j-3p
;
hsa-mir-548aq-3p
;
hsa-mir-548am-3p
;
hsa-mir-548aj-3p
;
hsa-mir-548ah-3p
;
hsa-mir-548ae-3p
;
hsa-mir-548z
;
hsa-mir-548h-3p
;
hsa-mir-548d-3p
;
hsa-mir-548bb-3p
;
hsa-mir-548ac
;
hsa-mir-3591-5p
;
hsa-mir-335-3p
;
hsa-mir-4639-5p
;
hsa-mir-4775
;
hsa-mir-4735-5p
;
hsa-mir-5196-3p
;
hsa-mir-4793-5p
;
hsa-mir-501-5p
;
hsa-mir-4255
;
hsa-mir-590-3p
;
hsa-mir-142-3p
;
hsa-mir-1303
;
hsa-mir-5096
;
hsa-mir-6848-3p
;
hsa-mir-6843-3p
;
hsa-mir-3187-3p
;
hsa-mir-4435
;
hsa-mir-588
;
hsa-mir-4701-5p
;
hsa-mir-548s
;
hsa-mir-516a-5p
;
hsa-mir-197-3p
;
hsa-mir-193b-5p
;
hsa-mir-6131
;
hsa-mir-4755-3p
;
hsa-mir-3663-5p
;
hsa-mir-150-5p
;
hsa-mir-4716-5p
;
hsa-mir-4781-3p
;
hsa-mir-483-5p
;
hsa-mir-4762-3p
;
hsa-mir-4303
;
hsa-mir-1911-5p
;
hsa-mir-4682
;
hsa-mir-624-5p
;
hsa-mir-6768-5p
Nearest miRNA
hsa-let-7i/Upstream/67417; hsa-mir-3612/Downstream/653590;
Nearest TSS
ENST00000382841/Upstream/20546;
ENST00000541924/Downstream/1262;
Nearest CpG islands
None/Target,
chr12-CpG: 104/Upstream/51145
,
chr12-CpG: 125/Downstream/112928
Upstream sequence
TCACTAAGTCAAACCCACCTTCTCTTGTAAAGAAACCTTATCTGACCCATTGCTGCTCACCTGACTTGCGGGTCTCTTTATGCTCTTTCTACATGGATAT
Downstream sequence
CAAAATGATTTCATCTGTAGAGCTTCCTCTGATAATAGCTCTATGTTCAGAGGGATTCTGAGGCTATGGTGAGGGTCACCGAAAAAAGGTACTTGCCCCA
Target sequence
CCTGTTCTATAGGTCGTGATCTCTGTGCCTGTTATTATATGTTCCCCTAACCTGAAATGACGACTTCTCCACCAATCCACATTCACTAAGTCAAACCCACCTTCTCTTGTAAAGAAACCTTATCTGACCCATTGCTGCTCACCTGACTTGCGGGTCTCTTTATGCTCTTTCTACATGGATAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT4
Sample type
PBMC
Age
39
Gender
Male
CpG Island Information
×
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