Basic Information
VIS ID
TVIS30015008
Fusion event
HIV-TMED2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
124073996/123589449 (Hg38)
End
124074118/123589449 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TMED2
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-193b-3p ; hsa-mir-615-3p ; hsa-mir-7-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-186-5p ; hsa-mir-4452 ; hsa-mir-219a-2-3p ; hsa-mir-3123 ; hsa-mir-4699-3p ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-6513-5p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-4303 ; hsa-mir-4425 ; hsa-mir-638 ; hsa-mir-4713-3p ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-4682 ; hsa-mir-4259
Nearest miRNA
hsa-let-7i/Upstream/52915; hsa-mir-3612/Downstream/747732;
Nearest TSS
ENST00000382841/Upstream/3887; ENST00000545042/Downstream/12628;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/4297, chr12-CpG: 80/Downstream/12221
Upstream sequence
TGCTGCTCCTGCTTCTTAATTAATATTAGAGTTACATGACTCTTAGACTTTATTTGTAGGATTACATTTTAAAAATACAGGTATTTATTTTGTGCTCTTA
Downstream sequence
TATATAGTATGTTTCCTACCCTGAAAGAGGTTTCTCTACTGGGAAGGGACTTTTAAAAATGCTTTGAGAATTAAATTGACATGATTCATATCAGTAGTCC
Target sequence
GTCCCCTCTCCTCAGTGTTTTACTACTTTTGCTGTAGTTAATAGTCAGTATAGTGAACTTCACATAACAACATTCCATTAGAAGAAATTTCCTGGGGTTGTTTTCCTTTCCTTAGTAAGCAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate