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Viral Integration Site DataBase
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TVIS30015014
Basic Information
VIS ID
TVIS30015014
Fusion event
HIV-TMED2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
124080553/123596006 (Hg38)
End
124080592/123596006 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TMED2
miRNAs that regulate target gene
hsa-mir-30a-5p
;
hsa-mir-193b-3p
;
hsa-mir-615-3p
;
hsa-mir-7-5p
;
hsa-mir-30c-5p
;
hsa-mir-30d-5p
;
hsa-mir-30b-5p
;
hsa-mir-30e-5p
;
hsa-mir-186-5p
;
hsa-mir-4452
;
hsa-mir-219a-2-3p
;
hsa-mir-3123
;
hsa-mir-4699-3p
;
hsa-mir-892c-3p
;
hsa-mir-4676-3p
;
hsa-mir-452-5p
;
hsa-mir-6513-5p
;
hsa-mir-5089-5p
;
hsa-mir-6728-5p
;
hsa-mir-769-3p
;
hsa-mir-450b-3p
;
hsa-mir-4303
;
hsa-mir-4425
;
hsa-mir-638
;
hsa-mir-4713-3p
;
hsa-mir-571
;
hsa-mir-219a-1-3p
;
hsa-mir-4682
;
hsa-mir-4259
Nearest miRNA
hsa-let-7i/Upstream/59472; hsa-mir-3612/Downstream/741175;
Nearest TSS
ENST00000382841/Upstream/10444;
ENST00000545042/Downstream/6071;
Nearest CpG islands
None/Target,
chr12-CpG: 104/Upstream/10854
,
chr12-CpG: 80/Downstream/5664
Upstream sequence
tactcccagctactcaggaggctgaggtggcaggattgcttgagtacagttcaaggttgcagtgaactatgattgtgtcatggcattccagcctgggcaa
Downstream sequence
GTTGCTTGGAGACAAAAGTATTTAGAGTATAGGTGACCCATAGGttacaatgacttcacttagaaattttcagctttatgatggtgcaaaagtgatgtgc
Target sequence
cagagcaaACAAAAAAGTCTTTGCTTTGGAGTATGTTGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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