Basic Information
VIS ID
TVIS30015015
Fusion event
HIV-DHX37 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
125456619/124972073 (Hg38)
End
125457191/124972073 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
DHX37
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-193b-3p ; hsa-mir-15b-5p
Nearest miRNA
hsa-let-7i/Upstream/56414; hsa-mir-3612/Downstream/3322019;
Nearest TSS
ENST00000382841/Upstream/5068; ENST00000341446/Downstream/8625;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/43454, chr12-CpG: 35/Downstream/16795
Upstream sequence
TCTGAGGCCAGGGACCGTGAAGACGCTCAAGGGCAAGCCCCAGCGGCCCCTCCCCTTTCCCTCAGCCTGAGGCTGGTACCCCACTCCGAGTCTGGTGCTG
Downstream sequence
GCTGTCGCCACGGGGCCACTACAAGGCAGGCCGTGGAGCAGGCAGGCGGCTTGAGGGCAGGGCCCGCTGGCAACCTGAAACAAGTCCCAGACATCTCCCC
Target sequence
CCCCTCACCAAACGCAACTGGACTCGAAGCTCCCAAGAGGGGGCTGTGTCTGGACCCGCCGCAGGGCAGAGCCTGCACACCACAGGCTTTCAGTACACCCCCGGCAAGGCGTGAACTCTGTGAGTCAGTCACAATaaaaatacaagttcacatttcacgagcaccttctaggtacgggccactgtgctaagctgtcagcatgcactctacaacttccgcttcaaaatgattctctaaggaatgcaccaacatact
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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