Basic Information
VIS ID
TVIS30015016
Fusion event
HIV-SFSWAP integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
132248252/131763707 (Hg38)
End
132248374/131763707 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
SFSWAP
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-let-7a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-let-7i/Upstream/3469529; hsa-mir-6763/Downstream/818290;
Nearest TSS
ENST00000382841/Upstream/5660; ENST00000537582/Downstream/19761;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/28713, chr12-CpG: 23/Downstream/15365
Upstream sequence
TTTCTTACAGGTGTGGAAAATGgtctaacataatgcctgtcacaaagtaggtaaaaatgtttgctgaataaaggcatGGATTCTGTAATTTTTGCTTTGT
Downstream sequence
tttaaaGAAAAATGAggccgggcacagtggctcacgtctataatcccagcactttgggaggccgaggcaggcggatcacgaggtcaggagatcaagacca
Target sequence
AAGAAAAGGCTATTTTTTATCATGGGGAATTTTTTAAAGAGACCTGTTTATAGTGGAGTCACATCATATGCCTCCTGAAGCAAATTTAGATATATGCTGAGCCATGaatttttttttttttt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate