Basic Information
VIS ID
TVIS30015020
Fusion event
HIV-XPO4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
21438770/20864631 (Hg38)
End
21438817/20864631 (Hg38)
Orient
+
Location type
Intronic
Target gene
XPO4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-877-3p ; hsa-mir-18a-3p ; hsa-mir-146b-5p ; hsa-mir-16-5p ; hsa-mir-6079 ; hsa-mir-3190-3p ; hsa-mir-3165 ; hsa-mir-6880-5p ; hsa-mir-8071 ; hsa-mir-6828-5p ; hsa-mir-873-5p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-4477a ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-130b-5p ; hsa-mir-16-1-3p ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-100-3p ; hsa-mir-548l ; hsa-mir-548n ; hsa-mir-671-5p
Nearest miRNA
hsa-mir-4499/Upstream/430785; hsa-mir-1267/Downstream/3297785;
Nearest TSS
ENST00000623511/Upstream/90673; ENST00000422510/Downstream/38116;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/90513, chr13-CpG: 80/Downstream/37989
Upstream sequence
agagatagagaggaaactgaggtcacatggctggtaaatgTTCCTTGAGCAATACTAATCTACCCTGAAACACACATGCCACTGAAGATAGAGCGAATAA
Downstream sequence
TTACATCCAAGCCTTTTTCTGCCCTTTGGAGGTGGGTGGGTGTTGGATGTGAGGGGGCAGTTATAGAAGATGAATATTCAAAATTTTCAAGACACAAAAG
Target sequence
GCACTTTCATTGTTAATGATCACTGAAACATTCCTAACTATTTGTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate