Basic Information
VIS ID
TVIS30015027
Fusion event
HIV-TOX4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.13
Reference genome
GRCh37/hg19
Start
46750461/46176326 (Hg38)
End
46750611/46176326 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOX4
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-6505-5p ; hsa-mir-7158-3p ; hsa-mir-203b-3p ; hsa-mir-613 ; hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-15b-3p ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-3685 ; hsa-mir-7975 ; hsa-mir-5571-3p ; hsa-mir-646 ; hsa-mir-548e-5p ; hsa-mir-384 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6847-3p ; hsa-mir-4767 ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-383-3p ; hsa-mir-3922-5p
Nearest miRNA
hsa-mir-2276/Upstream/1980126; hsa-mir-1267/Downstream/3820089;
Nearest TSS
ENST00000623511/Upstream/7807; ENST00000378805/Downstream/5878;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/123442, chr13-CpG: 93/Downstream/210223
Upstream sequence
aaaaatgtttgagatgatggatatgctgattaccctgatctcatcactagacattgtatgtattgaaacattactaggtaccccataaatacataccgtt
Downstream sequence
TCTAATTTTAAACTTTGCCTAAGGAATGCTGAATAGGGAAAATATGCAAATTTTATACAAATAACATTTGTGTATCCTTTTACTTCACACATTTGGATAC
Target sequence
atatgtcaatttaaaaataaaTAAAAACTGAAAAAACATTTTCAGGATGGAAGCTATATTGAATGCACACACATCTATTATAATCTCATGAATTATTATAAAAGGTTTTTATGGAAAAAAAGTTGCACCTGAGGTTAATAAAGATCCACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate