Basic Information
VIS ID
TVIS30015031
Fusion event
HIV-RB1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
49037333/48463197 (Hg38)
End
49037264/48463197 (Hg38)
Orient
-
Location type
Intronic
Target gene
RB1
miRNAs that regulate target gene
hsa-mir-106a-5p ; hsa-mir-26a-5p ; hsa-mir-23b-3p ; hsa-mir-335-5p ; hsa-mir-106b-5p ; hsa-mir-675-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-192-5p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-149-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-221-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-892a ; hsa-mir-3152-3p ; hsa-mir-4318 ; hsa-mir-4325 ; hsa-mir-3614-5p ; hsa-mir-4693-5p ; hsa-mir-6513-5p ; hsa-mir-26b-5p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-1258 ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-494-3p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-141-3p ; hsa-mir-590-5p
Nearest miRNA
hsa-mir-2276/Upstream/4266997; hsa-mir-1267/Downstream/1533218;
Nearest TSS
ENST00000623511/Upstream/18369; ENST00000531171/Downstream/13203;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/143476, chr13-CpG: 96/Downstream/69078
Nearest cancer related gene
RB1(TSG, No orient, 0)
Upstream sequence
AGAAAATCTGACATTTTAAAGTCACAGGGAATCATTTTCAGATCTTATTTTTGCATTTAAAATATCttttattgaaatgtaatacacatatgtaaaaacc
Downstream sequence
tgtgtatcaaaagtatacattctaacaaaaattcatcaactgagcttagttatataaccagcatccagatcaagaaacaaaacattgtcagcaacacata
Target sequence
TCATTTTCAGATCTTATTTTTGCATTTAAAATATCttttattgaaatgtaatacacatatgtaaaaacc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate