Basic Information
VIS ID
TVIS30015035
Fusion event
HIV-DACH1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
72178434/71604302 (Hg38)
End
72178645/71604302 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
DACH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-217
Nearest miRNA
hsa-mir-1297/Upstream/5385978; hsa-mir-1267/Downstream/6093710;
Nearest TSS
ENST00000623511/Upstream/589161; ENST00000618209/Downstream/262467;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1496215, chr13-CpG: 62/Downstream/260928
Nearest cancer related gene
DACH1(TSG, No orient, 0)
Upstream sequence
TTTTCCAATTAGTTAATTTTTCATTTATCTCATACTTTAAAATGTGCTTTAAAACCTAAGCACATATTTACTATAAAAATACTTACTGAATCAATAAACA
Downstream sequence
AACCGTTAAATGTTACTTTTCCAAGGTAGAAATTACGGCTTTATAAGCTTCCAATAATATGGTCTTTTTAGGAATTAAAACTAATGAAGGTGACATAACT
Target sequence
TCAAATCAAGTGATTAAGTAAAAATGAACTAAGTATCCTAACAGATAAATAAAAACAGACAAGCTAAATTTTTCAACTTTCCACAGTGGAACTTCACTACTTTGATATTCAATAGACCAACAGAAGAACCACTCCAGATGGACGACTGATTATAACTCATCCAATACCATTACCATGCACTCAGAAGAATGGACAATTTCTCATGAAACCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate