Basic Information
VIS ID
TVIS30015036
Fusion event
HIV-DIS3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
73350565/72776427 (Hg38)
End
73350679/72776427 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
DIS3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-30c-5p ; hsa-mir-6749-3p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-4698 ; hsa-mir-3146 ; hsa-mir-129-5p ; hsa-mir-450a-5p ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-6514-5p ; hsa-mir-4765 ; hsa-mir-640 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-802
Nearest miRNA
hsa-mir-1297/Upstream/6558103; hsa-mir-1267/Downstream/4921585;
Nearest TSS
ENST00000623511/Upstream/48499; ENST00000489797/Downstream/5427;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/48411, chr13-CpG: 80/Downstream/5138
Nearest cancer related gene
DIS3(OG, No orient, 0)
Upstream sequence
ttgggcacttgaaagacagatagtaccaccaagaaactgaatttttaatacatattaaatttaaatagtcatatataactaagtggctacatattagGGC
Downstream sequence
TATGTATAATGTCCTATCACTTAAAACCTATTTCTATAACAagggctaccatttatatttaccatacctatgtgccaggcactaggatgaaaattgtatt
Target sequence
AATACTAAATCTGTATTTCAAAAATCAAACCCAACTTTTATCTTCTCATTTCCTTTTGGTTTCATAAAGTATCATAAAGGTAAGAAGGGATGACAGAAGTGTAAAGACTGGATT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate