Basic Information
VIS ID
TVIS30015067
Fusion event
HIV-MIA2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
39760983/39291779 (Hg38)
End
39760684/39291779 (Hg38)
Orient
-
Location type
Intronic
Target gene
MIA2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-208a/Upstream/2339388; hsa-mir-1185-1/Downstream/8469216;
Nearest TSS
ENST00000550708/Upstream/15553; ENST00000556593/Downstream/21622;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/24081, chr14-CpG: 127/Downstream/139693
Upstream sequence
caagctaccaacatgatgtcactgaatgaggagtcttggaagataatgcttaaagtaggctttcctgagccaagtgtgatttggttAATTTTAAGGAAGG
Downstream sequence
AAAGTATGGTAATTTGTAATTTAGCTAAACTAAGACAGATTAGGGTAAGTGATGGGAGTGCCTTACTACTGTTTAGATGTGGACGTGTTGTAAAAAGCAC
Target sequence
ATAACTTTGTAAATTATGACAGTATTTGCTTTATTTTCATCCTGAGGATATTAAGAGCTAACTAGAATTAGGCCAGAGGTTTACGTTATAAGTAATGGTgtatgttggtaaatgtttgacaactttttttttaaaaagcagccttatttgtagcatttgctgagttctgtagtatgaatacttccaccatggccagtttcaagctaccaacatgatgtcactgaatgaggagtcttggaagataatgcttaaagt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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